Impaired T-cell differentiation in diabetic foot ulceration

Issues with Diabetic Foot Ulceration

The majority of foot ulcers appear to result from minor trauma in the presence of sensory neuropathy. This best describes the critical triad most commonly seen in patients with diabetic foot ulcers: peripheral sensory neuropathy, deformity, and trauma. All three of these risk factors are present in 65% of diabetic foot ulcers. Calluses, edema, and peripheral vascular disease have also been iden...

Diabetic Foot Ulceration and Amputation

Muscle perfusion scan for prediction of anticipated diabetic foot ulceration

Introduction:We evaluated the performance of muscle perfusion scan (MPS) to assess muscle perfusion reserve (MPR) for prediction of incident diabetic foot ulcerations (DFU). Methods: We recruited 41 diabetic patients without any history of DFU. Five mCi 99mTc-MIBI was injected intravenously during repetitive dorsal and plantar right foot flexions. T...

Wound Measurement in Diabetic Foot Ulceration

In this chapter the authors aim to provide a brief introduction to wound assessment in the diabetic foot and discuss the role of wound measurement within that assessment process. A literature review describing wound measurement in diabetic foot wounds was conducted and a review of wound measurement tools and techniques reported. The results of a wound measurement study using a particular techni...

Trials in Neuropathic Diabetic Foot Ulceration

D iabetic foot ulceration is a serious and expensive complication with considerable morbidity that affects up to 15% of diabetic patients during their lifetime; moreover, 80% of amputations are preceded by foot ulcers (1). Despite these facts, Mason et al. (2) concluded in their systematic review of treatments for foot lesions that the evidence base for treatments is poor. Furthermore, they cri...